Profile Dr. Franziska Haag

Research Group Taste & Odor Systems Reception

Lise-Meitner-Str. 34
85354 Freising
Tel.: +49 8161 71-2716


What´s the context?

Due to a maximal, individual genetic diversity of the odorant receptor genome, with the widespread occurrence of “specific anosmia” phenotypes, the mechanisms of a chemosensory-guided, receptor-related nutritional behavior are largely unknown.

What challenge is tackled?

Clarifying the mechanisms for an odorant receptor-related, genetically based consumer choice of foods.

What is done?

We perform large-scale high-throughput screening to assign cognate key food odorants to receptors, and human studies with individuals carrying a specific anosmia, to validate odorant-receptor coding.

What has come out of your work?

Identification of both narrowly and broadly tuned odorant receptors for key food odorants, and their dependence on e.g. food-dependent trace elements.

What´s the value?

Knowledge gained on odorant-receptor coding and receptor-related individual chemosensory phenotypes will guide the development of personalized nutrition and receptor-based, cell-free sensors for food quality control.

Since 2019 Senior Researcher – Odor Systems Reception & Biosignals at the Leibniz-Institute for Food Systems Biology at the Technical University of Munich (Leibniz-LSB@TUM)
07.06.2019 PhD Graduation (with excellence) at the Faculty of Chemistry of the Technical University of Munich
2013 – 2019 PhD student – Odor Systems Reception & Biosignals at the Leibniz-Institute for Food Systems Biology at the Technical University of Munich (Leibniz-LSB@TUM)
2011 – 2013 practical year 2. State examination Food Chemistry, Lower Saxony State Office for Consumer Protection and Food Safety, Germany
2006 – 2011 Diploma in Food Chemistry, TU Braunschweig, Germany
2020 Zukunftspreis der Lebensmittelchemischen Gesellschaft
2017 Student Travel Award, AchemS XL 2018, Bonita Springs, Florida USA

Head of the automated high-throughput screening facility of the Leibniz-LSB@TUM


  • Elucidation of odorant receptor coding (Bavarian project funding)
  • Finalization of the pyrazine/odorant receptor project
  • Cell-free system for the investigation of odorant receptors

Supervision of student interns and students for bachelor and master thesis


Kotthoff M, Bauer J, Haag F, Krautwurst D (2021) FASEB J, DOI: 10.1096/fj.202000182RR. Conserved C-terminal motifs in odorant receptors instruct their cell surface expression and cAMP signaling

Haag F, Ahmed L, Reiss K, Block E, Batista VS, Krautwurst D (2019) Cell Mol Life Sci, DOI: 10.1007/s00018-019-03279-y. Copper-mediated thiol potentiation and mutagenesis -guided modeling suggest a highly conserved copper-binding motif in human OR2M3

Noe F, Polster J, Geithe C, Kotthoff M, Schieberle P, Krautwurst D (2017) Chem Senses, 42 (3): 195-210, DOI: 10.1093/chemse/bjw118. OR2M3 – a highly specific and narrowly tuned human odorant receptor for the sensitive detection of onion key food odorant 3-mercapto-2-methylpentan-1-ol