Research Group Taste & Odor Systems Reception
Tel.: +49 8161 71-2716
What´s the context?
Due to a maximal, individual genetic diversity of the odorant receptor genome, with the widespread occurrence of “specific anosmia” phenotypes, the mechanisms of a chemosensory-guided, receptor-related nutritional behavior are largely unknown.
What challenge is tackled?
Clarifying the mechanisms for an odorant receptor-related, genetically based consumer choice of foods.
What is done?
We perform large-scale high-throughput screening to assign cognate key food odorants to receptors, and human studies with individuals carrying a specific anosmia, to validate odorant-receptor coding.
What has come out of your work?
Identification of both narrowly and broadly tuned odorant receptors for key food odorants, and their dependence on e.g. food-dependent trace elements.
What´s the value?
Knowledge gained on odorant-receptor coding and receptor-related individual chemosensory phenotypes will guide the development of personalized nutrition and receptor-based, cell-free sensors for food quality control.
|Since 2019||Senior Researcher – Odor Systems Reception & Biosignals at the Leibniz-Institute for Food Systems Biology at the Technical University of Munich (Leibniz-LSB@TUM)|
|07.06.2019||PhD Graduation (with excellence) at the Faculty of Chemistry of the Technical University of Munich|
|2013 – 2019||PhD student – Odor Systems Reception & Biosignals at the Leibniz-Institute for Food Systems Biology at the Technical University of Munich (Leibniz-LSB@TUM)|
|2011 – 2013||practical year 2. State examination Food Chemistry, Lower Saxony State Office for Consumer Protection and Food Safety, Germany|
|2006 – 2011||Diploma in Food Chemistry, TU Braunschweig, Germany|
|2020||Zukunftspreis der Lebensmittelchemischen Gesellschaft|
|2017||Student Travel Award, AchemS XL 2018, Bonita Springs, Florida USA|
Head of the automated high-throughput screening facility of the Leibniz-LSB@TUM
- Elucidation of odorant receptor coding (Bavarian project funding)
- Finalization of the pyrazine/odorant receptor project
- Cell-free system for the investigation of odorant receptors
Supervision of student interns and students for bachelor and master thesis
Kotthoff M, Bauer J, Haag F, Krautwurst D (2021) FASEB J, DOI: 10.1096/fj.202000182RR. Conserved C-terminal motifs in odorant receptors instruct their cell surface expression and cAMP signaling
Haag F, Ahmed L, Reiss K, Block E, Batista VS, Krautwurst D (2019) Cell Mol Life Sci, DOI: 10.1007/s00018-019-03279-y. Copper-mediated thiol potentiation and mutagenesis -guided modeling suggest a highly conserved copper-binding motif in human OR2M3
Noe F, Polster J, Geithe C, Kotthoff M, Schieberle P, Krautwurst D (2017) Chem Senses, 42 (3): 195-210, DOI: 10.1093/chemse/bjw118. OR2M3 – a highly specific and narrowly tuned human odorant receptor for the sensitive detection of onion key food odorant 3-mercapto-2-methylpentan-1-ol