Whats the context?
A couple of TRP (Transient receptor potential) channels are well known for the mediation of chemesthetic sensations, yet, their functions in non-sensory systems are less well understood.
What challenge is tackled?
Thus, clarifying the non-sensory function of these channels as well as identifying their endogenous ligands is of great scientific interest.
What is done?
Focusing on primary human immune cells the RNA-expression of TRP-channels as well as the cellular responses to known TRP-channel ligands are studied.
What has come out of your work?
These analyses showed that for example TRPV1 ligands from ginger modulate the human cellular immune response, indicating a natural role of this channel in the human immune system.
Whats the value?
Our work can provide a better general understanding regarding the function of chemosensory ion-channels in non-sensory systems.
since 2019 | Senior Researcher in the research group of Prof. Veronika Somoza |
2017-2019 | Head of the research group “Chemesthesis and Metabolism” at the Leibniz-Institute for Food Systems Biology at the Technical University of Munich (Leibniz-LSB@TUM) |
2008-2017 | Head of the research group “Food Composition Tables” at the DFA |
2005-2008 | Research scientist in the research group “Physiology” of Prof. Veronika Somoza at the then Deutsche Forschungsanstalt für Lebensmittelchemie (DFA) |
2004-2005 | Research scientist at the Botanical Institute, research group Plant Cell Biology, University of Kiel |
1999-2004 | PhD student at the Botanical Institute, research group Plant Cell Biology, University of Kiel |
1992-1999 | Studies in Food Chemistry at the University of Wuppertal |
Schoenknecht C, Andersen G, Schmidts I, Schieberle P. Quantitation of Gingerols in Human Plasma by Newly Developed Stable Isotope Dilution Assays and Assessment of Their Immunomodulatory Potential. J Agric Food Chem. 2016 Mar 23;64(11):2269-79. doi: 10.1021/acs.jafc.6b00030. Epub 2016 Mar 9. PMID: 26939769.
Schoenknecht C, Andersen G, Schieberle P. A novel method for the quantitation of gingerol glucuronides in human plasma or urine based on stable isotope dilution assays. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Nov 15;1036-1037:1-9. doi: 10.1016/j.jchromb.2016.09.033. Epub 2016 Sep 26. PMID: 27700987.
Andersen G, Marcinek P, Sulzinger N, Schieberle P, Krautwurst D. Food sources and biomolecular targets of tyramine. Nutr Rev. 2019 Feb 1;77(2):107-115. doi: 10.1093/nutrit/nuy036. PMID: 30165672.