Scientists of the Leibniz-LSB@TUM study the biological functions of sensory active and nutritious food ingredient systems and trace their effect on the human organism. To achieve this, chemists, biologists, engineers, informatics, and sensory scientists collaborate across their scientific disciplines – and they never run short of exciting news.
Attention: Research seminar in food chemistry starts
on October 14 at 5 pm with Prof. Dr. Jörg Bohlmann from the University of British Columbia, Canada.
The lecture's title is: "Montbretin A: A novel antidiabetic metabolite from the plant montbretia".
Prof. Dr. Katharina Scherf receives science award
The Heinrich Stockmeyer Foundation awarded Prof. Dr. Katharina Scherf the "Stockmeyer Science Prize" at the 59th Food Hygiene Workshop on 26 September 2019. With this award, the Foundation honours outstanding food science projects. The award-winning project impresses with practicable solutions and application-oriented research that contribute to improving food safety and consumer protection as well as strengthening consumer confidence in the quality and safety of food in line with the Foundation's purpose. The prize is endowed with 5,000 euros. Scherf receives the prize for the development of a test which is already commercially available and which determines the gluten content of cereal products very precisely.
On the trail of celiac disease triggers
Celiac disease is a chronic inflammatory bowel disease that has characteristics of an autoimmune disease. It is triggered by the consumption of gluten in genetically predisposed people. In addition to gluten, the body's own enzyme, tissue transglutaminase, plays a decisive role in the development of the disease. On the one hand, the enzyme changes the structure of the gluten fragments, which were formed during its digestion in the gut. On the other hand, it binds the gluten fragments firmly to itself. Scientists assume that these enzyme-gluten fragment complexes lead to the formation of autoantibodies. A recent Leibniz-LSB@TUM study provides new insights into the structure of these complexes. The findings could contribute to a better understanding of the role of the body's own enzyme in triggering celiac disease.
Funding: This research project (No. 250645717) was funded by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG, Bonn). The publication of this article was funded by the Open Access Fund of the Leibniz Association.
On the trail of bitter-tasting proteins
Fermented foods such as cheese or yoghurt contain numerous non-volatile substances that shape the taste profile of the respective food. These also include bitter-tasting fragments of long protein molecules that are formed during cheese ripening, for example. Researchers at the TU Munich and the Leibniz-LSB@TUM have now developed two new mass spectrometry-based analytical procedures which can be used to detect taste-active protein fragments in fermented foods in a very time-saving and comprehensive manner.
Funding: This research project (AiF 18124 N) by the Research Association of the German Food Industry (FEI) received funding from the “Otto von Guericke” Federation of Industrial Research Associations as part of the Industrial Collective Research program by the Federal Ministry for Economic Affairs and Energy pursuant to a parliamentary resolution by the German Bundestag.
Original wheat species are rich in protein
Original wheat species such as emmer, spelt and einkorn have a higher protein and gluten content than bread and durum wheat. In addition, the old species require less nitrogen fertilizer to produce the same protein yields as conventional wheat species. These are the findings of a new study in which scientists of the Leibniz-LSB@TUM were significantly involved. The new findings could contribute to breeding new cereal varieties with improved qualities for more sustainable agriculture.
Publication:Geisslitz S, Longin CFH, Scherf KA, Koehler P (2019) Foods, 8: 409, DOI: 10.3390/foods8090409. Comparative study on gluten protein composition of ancient (einkorn, emmer and spelt) and modern wheat species (durum and common wheat)
Funding: This IGF project of the FEI was supported via AiF within the program for promoting the Industrial Collective Research (IGF) of the German Ministry of Economics and Energy (BMWi), based on a resolution of the German Parliament (Project AiF 18355 N).
The difference in scent between rice and wheat bread
People affected by coeliac disease must avoid bread containing gluten. They therefore often resort to gluten-free products such as rice bread. A new study has investigated which key odorants are responsible for odor differences between rice and wheat bread. It also shows which measures could be taken to optimise the aroma and thus also the quality of rice bread. Researchers of the Leibniz-LSB@TUM played a leading role in the study.
Publication: Boeswetter AR, Scherf KA, Schieberle P, Koehler P (2019) J Agric Food Chem, DOI: 10.1021/acs.jafc.9b04800. Quantitative analyses of key odorants and their precursors reveal differences in the aroma of gluten-free rice bread compared to wheat bread
Funding: This IGF Project of the FEI was supported via AiF within the programme for promoting the Industrial Collective Research (IGF) of the German Ministry of Economic Affairs and Energy (BMWi), based on a resolution of the German Parliament (Project CORNET AiF 147 EN “GLUeLESS”).
All the best for the future!
PD Dr. Katharina Scherf has now received a W1 professorship with tenure track (W3) at the Karlsruhe Institute of Technology following her successful habilitation at the TUM. She will be working at the institute from 01.08.2019. She will head the Department of Bioactive and Functional Food Ingredients at the Institute of Applied Biosciences.
The Leibniz-LSB@TUM congratulates Dr. Scherf on her appointment and thanks her very much for her excellent work in the field of research on biopolymers, gluten and cereals as well as on the causes of wheat intolerances. Ms. Scherf has received several awards for her outstanding achievements as a talented, leading scientist at the institute. Among others, she received the Young Scientist Research Award at the 2018 AACC International Annual Meeting in London, UK, and the 2019 Research Award of the German Celiac Disease Society. The latter is associated with a research grant of 20,000 euros. The Institute is proud to have produced such a successful young scientist. For the future we wish her all the best and continued success for her career!
Better food quality control‒Food profilers develop new methodological approach for food analysis
Freising, July 30, 2019
Scientists at the Technical University of Munich (TUM) and the Leibniz-Institute for Food Systems Biology have developed a new methodology for the simultaneous analysis of odorants and tastants. It could simplify and accelerate the quality control of food in the future.
New gluten test is reliable
Under the leadership of PD Dr. Katharina Scherf from Leibniz-LSB@TUM, 19 laboratories from all over the world have tested whether a new gluten test lives up to its promise. The new gluten ELISA test kit is the first to use four different antibodies simultaneously. As the researchers show, the test is able to detect gluten contaminations in oats and oat products derived from wheat, rye and barley. This is a decisive advantage over the antibody-based tests previously used, which only detect a specific gluten fraction (prolamins).
The new test kit (RIDASCREEN® Total Gluten, R7041) is a result of the BMBF-funded joint project "Fluorescence optical rapid test system for the sensitive detection of gluten (GLUTEVIS)".
Publication: Lacorn M, Weiss T, Wehling P, Arlinghaus M, Scherf K (2019) J AOAC Int, DOI: 10.5740/jaoacint.19-0094. Quantification of wheat, rye, and barley gluten in oat and oat products by ELISA RIDASCREEN® Total Gluten: Collaborative study, First Action 2018.15
Complementary Publication: Wehling P, Scherf KA (2019) J AOAC Int, DOI: 10.5740/jaoacint.19-0081. Preparation of validation materials for estimating gluten recovery by ELISA according to SMPR 2017.021
Pharmaconutrition‒Modern drug design for functional studies
Freising, July 1, 2019
Antonella Di Pizio and Maik Behrens of the Leibniz-Institute for Food Systems Biology at the Technical University of Munich, together with their cooperation partners, have developed highly effective activators for the bitter receptor TAS2R14 in a German-Israeli research project. The new substances are used to investigate the as yet unknown physiological functions of the receptor, for example, in the human immune system.
The team of scientists published their results in the journal Cellular and Molecular Life Sciences (Di Pizio et al., 2019; DOI: 10.1007/s00018-019-03194-2).
Research prize of the German Celiac Disease Society
PD Dr. Katharina Scherf has been awarded the research prize of the German Celiac Disease Society (DZG e.V.) for the research project "Verification of the reliability of a portable sensor for consumers for the detection of gluten". The prize is associated with a research grant of 20,000 euros.
June 15, 2019: Long Night of Sciences in Berlin
From 5 to 12 pm, at the Long Night of Sciences in Berlin, scientists of the Leibniz-LSB@TUM presented their research together with partners from the Leibniz Research Alliance "Sustainable Food Production and Healthy Nutrition" at the Headquarter of the Leibniz Association.
8. Round Table Cocoa Hamburg
June 13th - 14th 2019 - Researchers of the Leibniz-LSB@TUM presented new results of their research. Among other things, biochemical and quality changes of cocoa along the processing chain were discussed.
Lecture series "Facets of Food Chemistry" in Hamburg
On June 05, 2019 PD Dr. Katharina Scherf from the Leibniz-LSB@TUM will give a lecture at the University of Hamburg on the topic: Neue Methoden zur Detektion von Gluten aus Weizen, Roggen und Gerste in Lebensmitteln für Zöliakie-Betroffene
Manfred Rothe Excellence Award in Flavor Research
On May 23, Dr. Antonella Di Pizio of the Leibniz-LSB@TUM has been awarded the platinum edition of the Manfred Rothe Excellence Award in Flavor Research at the 12th Wartburg Symposium. The purpose of the award is to honor and stimulate researchers for excellent contributions to aroma and taste research.
The scent of jackfruit pulp
Researchers at Leibniz-LSB@TUM have identified 35 key odorants that cause the typical jackfruit pulp aroma. The data will provide a basis for further studies on the aroma differences between jackfruit varieties and studies aimed to elucidate the molecular background of aroma changes during jackfruit processing. The data may also be used to aid in the development of new jackfruit cultivars with superior aroma properties by targeted breeding.
12th Wartburg Symposium on Flavour Chemistry & Biology
May 21-24, 2019 | Eisenach/Germany
Scientists of the Leibniz-LSB@TUM participate:
Today (May 21, 2019) Dr. Maik Behrens gives a lecture on the topic: Taking fingerprints of the evolution - Bitter taste receptor gene repertoires.
Followed by Dr. Patrick Marcinek with a lecture on: Selective chemoreception of food-relevant pyrazines relates to evolutionary conserved detection of semiochemicals.
Further information: http://www.wartburg-symposium.de
Nitrogen fertilization influences the baking quality of wheat flour–Less is sometimes more
An international team of scientists has investigated the extent to which late nitrogen leaf fertilisation of wheat can contribute to an improved baking quality of wheat flour. As the new study shows, late fertilisation only optimises the baking quality if the plants had a low nitrogen uptake due to unfavourable environmental conditions. In particular, fertilization with 100 kg nitrogen per hectare led to an optimal protein composition in the wheat grain and thus achieved a high baking quality of the flour. The Leibniz-LSB@TUM was also involved in the study.
Publication: Rossmann A, Buchner P, Savill GP, Hawkesford MJ, Scherf KA, Mühling KH (2019) Eur J Agron, DOI: 10.1016/j.eja.2019.04.004. Foliar N application at anthesis alters grain protein composition and enhances baking quality in winter wheat only under a low N fertiliser Regimen
Lecture series "Facets of Food Chemistry" in Hamburg
On May 08, 2019 PD Dr. Steinhaus from the Leibniz-LSB@TUM will give a lecture at the University of Hamburg on the topic:
Geruchsaktive Verbindungen in Lebensmitteln: Bedeutung, Analytik und Anwendung zur Verbesserung der sensorischen Produktqualität (Odour-active compounds in food: Significance, analysis and application for the improvement of sensory product Quality)
Optimizing fresh cheese production
A team of scientists led by the University of Hohenheim has now refined a new method for the production of fresh cheese. Microfiltration makes it possible to produce fresh cheese in such a way that it tastes less bitter and that sweet whey is produced as a by-product that can be easily processed. The decisive factor is that the calcium-protein ratio of the milk retentate is decreased to ≤ 15.9 mg/g prior to fermentation. Researchers from Leibniz-LSB@TUM and TU Munich were also involved in the project.
Publication: Schäfer J, Sebald K, Dunkel A, Hofmann T, Rosenthal I, Schuster R, Atamer Z, Hinrichs J (2019) Int Dairy J, 93: 72-80, DOI: 10.1016/j.idairyj.2019.01.012. A feasibility study on the pilot scale manufacture of fresh cheese from skim milk retentates without acid whey production: Effect of calcium content on bitterness and texture
Funding: This IGF Project of the FEI was supported via AiF within the programme for promoting the Industrial Collective Research (IGF) of the German Ministry of Economic Affairs and Energy (BMWi), based on a resolution of the German Parliament (Projects AiF 18124 N und 19688 N).
WSR013 How does our sense of smell work?
Interview with PD Dr. Dietmar Krautwurst (April 14, 2019)
Bernd Rupp and André Lampe of the Wirkstoffradio were guests at the Leibniz-LSB@TUM and spoke with several researchers about the chemosensory systems.
(In German language only)
Skin Care: Micelles
Facial toner in the check
PD Dr. Martin Steinhaus in interview with BR-TV Gesundheit (April 9, 2019)
(In German language only)
New findings on the effect of Epsom salt - Epsom salt receptor identified
A team of scientists headed by Maik Behrens from the Leibniz-Institute for Food Systems Biology at the Technical University of Munich has identified the receptor responsible for the bitter taste of various salts. These include medically used Epsom salt. The discovery helps to elucidate the physiological mechanisms by which Epsom salt affects the heart or gut.
Improving bread quality through kneading
Wheat dough with a high content of mechanically modified starch requires longer kneading times than bread dough made from standard flour. An extended kneading time improves the microstructure of the dough and increases the bread volume by almost 25 percent. This is a result of a new cooperation study conducted by the TU Munich and the Leibniz-LSB@TUM.
Publication: Hackenberg S, Vogel C, Scherf KA, Jekle M, Becker T (2019) Food Chem, 290: 64-71, DOI: 10.1016/j.foodchem.2019.03.016. Impact of altered starch functionality on wheat dough microstructure and its elongation behavior
Funding: This IGF Project of the FEI was supported via AiF within the programme for promoting the Industrial Collective Research (IGF) of the German Ministry of Economic Affairs and Energy (BMWi), based on a resolution of the German Parliament (Project AIF 18679N).
Seminar by Dr. Antonella Di Pizio at the Forschungszentrum Jülich
On April 02, Dr. Antonella Di Pizio from the Leibniz-LSB@TUM gave a seminar lecture at the Forschungszentrum Jülich. The title of the lecture was: From chemistry to biology and back: molecular recognition of bitter molecules
News about gluten and wheat allergy
WDEIA (wheat-dependent exercise-induced anaphylaxis) is a rare form of wheat allergy. Physical activity, alcohol or certain medications are suspected of increasing the absorption of gluten components (gliadins) from the intestine into the blood and thus triggering the allergy. As a new study shows, the blood levels of gliadins are independent of the named factors ̶ at least in healthy persons. Neither did the researchers observe a correlation between gliadin levels and zonulin, a marker for the permeability of the intestinal barrier. The Leibniz-LSB@TUM was significantly involved in the study.
Publication: Scherf KA, Lindenau A-C, Valentini L, Collado MC, García-Mantrana I, Christensen MJ, Tomsitz D, Kugler C, Biedermann T, Brockow K (2019) Clin Transl Allergy, 9: 19, DOI: 10.1186/s13601-019-0260-0. Cofactors of wheat dependent exercise-induced anaphylaxis do not increase highly individual gliadin absorption in healthy volunteers
Funding: This work was supported by the German Research Foundation (DFG) and the Technical University of Munich (TUM) in the framework of the Open Access Publishing Program.
Girls'Day at the Leibniz-LSB@TUM
On March 28, 2019, our young guests were given an insight into the research of our institute. They learned a lot about the job of a bioinformatician and enjoyed the day very much. Many thanks to all those who contributed to the success of the event.
Beyond the flavour – Chemoreceptors offer approaches for the development of new drug therapies
Odour and taste receptors are not only found in nose or mouth. Recent studies indicate that they also take on other functions in the body, for example in the immune system or the regulation of metabolism. Therefore, they could serve as starting points for the computational development of new therapeutics. A new review article of the Leibniz-LSB@TUM summarises the current data on this topic.
Funding: This work was supported by the TUM in the framework of the Open Access Publishing Program.
Determining the benzene content of foods safely
Benzene is carcinogenic. For this purpose, it is important to accurately determine the benzene content in flavoured foods, such as cherry-flavoured drinks. A team of scientists from the Leibniz-LSB@TUM and the TU Munich has now developed a new, reliable analytical method that can detect even the smallest amounts of benzene in foods.
Publication: Frank S, Hofmann T, Schieberle P (2019) Eur Food Res Technol, DOI: 10.1007/s00217-019-03267-3. Quantitation of benzene in flavourings and liquid foods containing added cherry-type flavour by a careful work-up procedure followed by a stable isotope dilution assay
Funding: This research project was supported by the German Ministry of Economics and Energy (via AiF) and the FEI (Forschungskreis der Ernährungsindustrie e.V., Bonn). Project AiF 18813 N.
The scent of gluten-free rice flour and bread
People affected by the small intestinal disorder celiac disease must avoid gluten-containing bread. They therefore often resort to gluten-free substitutes such as rice bread. A new study has now for the first time identified the key odorants that characterize the scent of gluten-free rice flour or rice bread. The results could help to optimize the aroma and thus the quality of gluten-free baked goods. Researchers from Leibniz-LSB@TUM were significantly involved in the study.
Publication: Boeswetter AR, Scherf KA, Schieberle P, Koehler P (2019) J Agric Food Chem, 67: 2963-2972, DOI: 10.1021/acs.jafc.9b00074. Identification of the key aroma compounds in gluten-free rice bread
Funding: This research project was supported by the German Ministry of Economics and Energy (via AiF) and the FEI (Forschungskreis der Ernährungsindustrie e.V., Bonn) (project CORNET AiF 147 EN “GLUeLESS”).
Olfactory profiles of propolis
Propolis is a fragrant, sticky material produced by bees. It has antimicrobial properties and is used by food manufacturers as well as cosmetic producers. A US study has now investigated the olfactory profiles of propolis samples from a New Jersey beehive over a period of three years. The results will help to develop new methods for quality control of propolis. The Leibniz-LSB@TUM was also involved in the study.
Publication: Tomaszewski M, Dein M, Novy A, Hartman TG, Steinhaus M, Luckett CR, Munafo JP Jr (2019) J Agric Food Chem, 67: 1495−1503, DOI: 10.1021/acs.jafc.8b05965. Quantitation and seasonal variation of key odorants in propolis
Bioelectronic tongue developed for bitter compounds
An international research team, including the Leibniz-LSB@TUM, has developed a cell-based “bioelectronics tongue”. It is used to specifically identify bitter substances containing a thiourea or isothiocyanate group. Previous studies suggest that some of these compounds are anti-cancerogenic. The new test system could therefore be used both in future food and pharmaceutical studies.
Publikation: Qin C, Qin Z, Zhao D, Pan, Zhuang L, Wan H, Di Pizio A, Malach E, Niv MY, Huang L, Hu N, Wang P (2019) Talanta, DOI: 10.1016/j.talanta.2019.02.021. A bioinspired in vitro bioelectronic tongue with human T2R38 receptor for high-specificity detection of N-C=S-containing compounds
Wheat proteins and immune system
Wheat is an important nutrient source, which also contributes to our protein supply. However, gluten and non-gluten proteins have been identified as allergens or triggers of celiac disease. A new article by the Leibniz-LSB@TUM now provides an overview about wheat proteins and the immune system.
Funding: This work was supported by the Leibniz Association within the Leibniz Competition 2016 (project WHEATSCAN, K195/2015).
What are taste receptors doing in the brain?
Taste receptors are not just for tasting. They are also found on cells of organs that are involved in the hormonal regulation of the body. These include the brain, the pancreas or the thyroid gland. A new review article of the Leibniz-LSB@TUM summarizes what scientists have discovered so far about possible functions of taste receptors in the (neuro)endocrine system.
Rapeseed doesn't just contain oil but high-quality protein, too. However, protein extracts from rapeseed have an intense, bitter off-taste. A team led by food chemist Thomas Hofmann has now identified the substance that is pivotal for the bitter taste. This is a first step towards developing rapeseed for the human protein supply.
Food chemist has been awarded the scientific prize of the Verband Deutscher Großbäckereien
On January 17, 2019, Kathrin Schalk has been awarded the scientific prize of the Verband Deutscher Großbäckereien at the 48th Wissenschaftlichen Informationstagung der Berlin-Brandenburgischen Gesellschaft für Getreideforschung e.V. in Berlin. The award honors her outstanding dissertation entitled "Development of targeted mass spectrometric methods for the quantification of gluten-specific peptides in foods".
A new study by the Leibniz-Institute for Food Systems Biology at the Technical University of Munich (Leibniz-LSB@TUM) shows that craft beer should be kept cool and consumed as fresh as possible. After three months, cold stored beer already loses more than one third of an important hop odorant which characterizes the typical aroma of many craft beers. Storage at room temperature causes the concentration of this substance to decrease even more significantly.
Martin Steinhaus and Klaas Reglitz from the Leibniz LSB@TUM recently published their findings in the journal BrewingScience, doi.org/10.23763/BRSC18-13STEINHAUS.
Life sciences for the senses
November 15, 2018
PD Dr. Dietmar Krautwurst presented some of his latest research findings at the 16th journalist workshop of the Promega GmbH. He heads section II of the Leibniz-LSB@TUM. Amongst others, he and his team investigate the function of olfactory receptors, which are not only found in the nose, but also on cells of the immune system (leukocytes).
Why einkorn could be better for people with wheat intolerance
Modern, but also original types of wheat naturally contain a group of proteins, which might cause symptoms of wheat intolerance. A new study by the Leibniz-Institute for Food Systems Biology at the Technical University of Munich shows for the first time that in comparison to common wheat, spelled and emmer, einkorn contains no or significantly lower amounts of these proteins. Researchers have now published their findings in the Journal of Agricultural and Food Chemistry.
Our Booth at the 18th Public Science Days in Munich
Our topic: Working World Food Research 4.0
Making cheese & co. taste better – The hunt for flavor-giving fragments
Freising, November 6, 2018
Researchers at the Technical University of Munich (TUM), the Leibniz-Institute for Food Systems Biology, and the University of Hohenheim have developed a new methodical approach. It allows for the faster identification of flavor-giving protein fragments in foods such as cheese or yogurt, thus optimizing production processes.
FEMA Excellence in Flavor Science Award 2018
October 22, 2018
Prof. Dr. Thomas Hofmann has been awarded the FEMA Excellence in Flavor Science Award 2018 at the FEMA 49th Fall Symposium in New York, USA. The Flavor and Extract Manufacturers Association of the United States (FEMA) is comprised of flavor manufacturers, flavor users, flavor ingredient suppliers, and others with an interest in the U.S. flavor industry. One of their most noted developments was the FEMA GRAS list, promoting the generally recognized as safe concept for flavoring substance evaluations. "The FEMA Excellence in Flavor Science Award was created by the FEMA Board of Governors to recognize individuals who have shown outstanding dedication to the advancement of flavor science", according to FEMA. The globally renowned award may be bestowed to highly-recognized researchers and esteemed experts of their field. Prof. Hofmann is the most recent award recipient, following other acclaimed experts like Prof. Wolfgang Meyerhof (2014) and Prof. Peter Schieberle (2008).
2018 AACC International Young Scientist Research Award
October 22, 2018
Dr. Katharina Scherf has been awarded the 2018 AACC International Young Scientist Research Award. The Young Scientist Research Award is presented to an individual for outstanding contributions in basic and applied research to cereal science with the expectation that contributions will continue.
Thomas Hofmann elected as TUM’s new President
Freising October 17, 2018
The Board of Trustees of the Technical University of Munich (TUM) has elected Prof. Thomas Hofmann (50) as the new President of TUM. The experienced university manager has held the position of Senior Vice President Research and Innovation at TUM since 2009. He made a significant contribution to TUM’s success in the Excellence Initiative, especially in developing the internationally acclaimed “TUM Faculty Tenure Track” recruitment and career system. Under his guidance, TUM also became Germany’s top university for the establishment of start-ups. The holder of the Chair of Food Chemistry and Molecular Sensory Science has received multiple awards for his research and teaching. On October 1, 2019, Hofmann will take over from Prof. Wolfgang A. Herrmann, whose far-reaching reforms in his 23-year tenure saw TUM rise to international top level.
New gluten test on the test bench
For the first time a gluten ELISA test uses four different antibodies simultaneously. Thus, it is able to detect gluten fractions from wheat, rye and barley that contaminate oats and oat products. This is a decisive advantage over previously used antibody-based assays. Over the past three weeks, 19 laboratories from around the world led by Dr. Katharina Scherf from the Leibniz-LSB@TUM have analysed whether the test kit indeed determines reliably gluten contaminations in oats and oat products. The results will be available shortly.
The new test kit (RIDASCREEN® Total Gluten, R7041) is a result of the BMBF-funded joint project "Fluoreszenzoptisches Schnelltestsystem für den sensitiven Nachweis von Gluten (GLUTEVIS)".
Bitterless cough syrup
An international team of scientists has developed a set of bitterless prodrugs for a bitter tasting expectorant. In the future these prodrugs could contribute to reduce the bitterness of well-tried cough syrups, as they do not activate the bitter taste receptor TAS2R14 on the tongue. The substances are stable at neutral pH. Only gastric acid converts them into the active, bitter-tasting expectorant guaifenesin. Toddlers in particular often reject bitter medicine and would benefit from bitterless cough syrup.
Researchers from the Leibniz-LSB@TUM were also involved in the cooperation project.
Publication: Thawabteh A, Lelario F, Scrano L, Bufo SA, Nowak S, Behrens M, Di Pizio A, Niv MY, Karaman R (2018) Chem Biol Drug Des, DOI: 10.1111/cbdd.13409. Bitterless guaifenesin prodrugs – design, synthesis, characterization, in vitro kinetics and bitterness studies
Open House Day 2018 at Leibniz-LSB@TUM
Visit our institute in Freising/Weihenstephan.
This is your chance to experience science and research up close and personal – in the anniversary year 2018 at all TUM locations. At the open house day, on October 13, from 11 am to 5 pm, we invite you to visit also our institute providing fascinating insights into our research. Join us to test your chemical senses. Learn more about aroma, smell and taste or why sweetners sometimes taste bitter. Expand your knowledge about wheat intolerances and gluten.
In addition to interactive exhibits, interesting discussions with scientists, we also offer guided tours through our laboratories.
When: Saturday, October 13, 2018, from 11 am to 5 pm
Where: Lise-Meitner-Straße 34, 85354 Freising
We are easy to reach via the TUM bus shuttle!
You will find further information here.
enable 2.0: Risk markers for childhood obesity
Obesity in children is a serious public health problem. Affected children usually carry over extra pounds into adulthood. Obesity in general increases the risk of cardiovascular diseases, diabetes and certain types of cancer. In order to prevent this fatal development, it will be necessary to identify children at-risk as early as possible.
enable is one of four clusters about nutrition research funded by the Federal Ministry of Education and Research (BMBF). Both the Leibniz-LSB@TUM as well as the Chair of Food Chemistry and Molecular Sensory Science at TUM are involved in the joint project–each of them with an own subproject. In order to develop new nutritional strategies against childhood obesity, both institutions work together with the Dr. von Haunerschen Children's Hospital of the LMU. Their goal is to identify biomarkers that can help to detect highly vulnerable children already at babyhood.
Participating researchers at the Leibniz-LSB@TUM: Prof. Thomas Hofmann, PD Dr. Dietmar Krautwurst, Dr. Patrick Marcinek and Andreas Dunkel.
Bioflavour 2018 - Biotechnology of Flavours, Fragrances and Functional Ingredients
18. - 21. September 2018 DECHEMA-Haus, Frankfurt am Main
Keynote Speakers from Leibniz-LSB@TUM:
From flavours to bioactives – chemoreceptors you always meet twice
Strategies for the discovery of novel aroma-active key compounds in foods
New AiF project launched: "Heat makes the difference: fruit juices in comparison"
There are different methods to preserve juices. In addition to classic heat pasteurization, there are also gentle manufacturing processes in which the relatively high thermal load of the products is eliminated. This helps to preserve the natural aroma, the fresh taste and a high content of secondary plant compounds in the juice.
The quality of the juice has changed dramatically after classical pasteurisation. Nevertheless, the market often offers products labelled as carefully manufactured that are based on heat-pasteurized juices. Frequently, such juices are sold at the same price as completely carefully produced, high-quality direct juices. This is a disadvantageous for both consumers and manufacturers of high quality products. However, so far no simple but precise detection methods exist to prove such misrepresentation.
The aim of the new research project is to develop suitable detection methods to identify false marketing of direct juices. Apart from PD Dr. Martin Steinhaus and Eva Bauersachs from Leibniz-LSB@TUM, Prof. Andreas Schieber's team from the University of Bonn is involved in the cooperation project.
The project is funded by the Forschungsvereinigung Forschungskreis der Ernährungsindustrie e.V. (FEI) and the Arbeitsgemeinschaft industrieller Forschungsvereinigungen „Otto von Guericke“ e.V. (AiF) via the Federal Ministry for Economic Affairs and Energy. Read more...
Food ingredient with potential side effects
Tyramine is a natural, bioactive substance that we ingest via various foods. In particular certain cheeses such as Roquefort or soy sauce may contain larger quantities. Excessive intake or simultaneous use of certain medications may cause toxic effects, extreme hypertension, pseudoallergic reactions, and migraine.
Scientists of the Leibniz LSB@TUM have now compiled quantitative data on the tyramine content of more than 100 foods in a review article. In addition, they describe the factors that influence the concentration of the biogenic amine, as well as the molecular targets through which tyramine exerts its effects in the human body.
Flour quick test improved
New results of a comparative study between ancient and modern wheat species make it now possible to predict the baking quality of spelled, emmer and einkorn wholemeal flour quickly and reliably. "In future, the new results of Leibniz-LSB@TUM could help to replace time-consuming and expensive preliminary investigations in the laboratory", says Dr. Katharina Scherf, head of the working group Functional Biopolymer Chemistry at Leibniz-LSB@TUM. Publication...
German press release!
The project was funded by the Forschungsvereinigung Forschungskreis der Ernährungsindustrie e.V. (FEI) and the Arbeitsgemeinschaft industrieller Forschungsvereinigungen „Otto von Guericke“ e.V. (AiF) via the Federal Ministry for Economic Affairs and Energy.
Bitter taste receptor in the gut acts anti-diabetic
The synthetic analogue of isohumulone, the hop-derived bitter principle in beer, mediates its anti-diabetic action via a bitter taste receptor in the gastrointestinal tract – as shown in mice. Thus, targeting extraoral bitter taste receptors may be useful in metabolic disease treatment.
This is a result of an international cooperation project of the Scripps Research Institute in La Jolla, USA, in which Dr. Maik Behrens from the Leibniz-LSB@TUM is also involved. Read more...
Whitecap: Beer a cultural asset
Thomas Hofmann, Director of the Leibniz-LSB@TUM, in a talk with "leibniz" the magazine of the Leibniz Association. Subject of the talk: Indulgence and art of brewing
"Milestone" wheat gene map could help food security and allergies
Scientists have mapped out more than 94% of the genome of Chinese Spring bread wheat — adding that by manipulating its genetic code, people could eventually improve global food security and possibly alleviate some immune disorders like celiac disease or wheat allergies.
"[This] is a true milestone in wheat research. This is the foundation for future breeding strategies that will help develop improved wheat cultivars that are resistant to climate change, pests and pathogens while providing good agricultural performance in terms of yield and nutrient density“, comments Katharina Scherf of the Leibniz-LSB@TUM. Read more...
The program of the AACC International Meeting in London is now available!
Dr. Katharina Scherf is Program Team Chair of the AACC International Meeting in London that will take place in October 2018. She is responsible for the organization of the scientific program that now is available. At the Leibniz-LSB@TUM she heads the research group Functional Biopolymer Chemistry. You can find further information about the meeting here.
Comparison of Gluten Test Kits
Gluten contained in cereals such as wheat can cause celiac disease in hereditary predisposed people. Therefore, reliable analytical methods are needed to ascertain that gluten-free products contain less than 20 mg/kg gluten. A team around Dr. Katharina Scherf from the Leibniz-LSB@TUM has now compared the reliability of different immunological test kits for gluten. As study results show, there are some major differences between the kits, especially in the detection of gluten from spelt, durum wheat, emmer and einkorn. The study results indicate that there is still a demand for optimizing gluten test kits.
Schopf M, Scherf KA (2018) Journal of Cereal Science 83: 32-41, Wheat cultivar and species influence variability of gluten ELISA analyses based on polyclonal and monoclonal antibodies R5 and G12.
Exchange of views on nutrition issues
July 19, 2018: Hans-Joachim Fuchtel, Parliamentary State Secretary at the Federal Minister of Food and Agriculture and Member of the German Bundestag visits the Leibniz-LSB@TUM. Prof. Dr. Hofmann gave an insight into the current research of the Leibniz-Institute.
The Molecular World of Odors: From first violin to sensory sound
July 06, 2018
On the occasion of the Academic Anniversary Celebration of the Faculty of Natural Sciences and Technology of the University of Siegen, Thomas Hofmann gave a lecture on the topic: The Molecular World of Odors: From first violin to sensory sound.
100 Years of Molecular Food and Nutrition Research
The Leibniz-Institute for Food Systems Biology at the Technical University of Munich celebrated its 100th anniversary on 15 June 2018.
Greetings to the institute and impressions of the celebration.
16.7 million Euro for investment in a modern research infrastructure
The Bavarian State Ministry of Economic Affairs, Energy and Technology is convinced of the potential of the Leibniz-Institute. Therefore it will provide almost 17 million Euros for investment in a modern research infrastructure. In doing so they are further expanding the strong position of the institute as a driver of innovation.
June 15, 2018: Leibniz-LSB@TUM celebrates its 100th anniversary
Research for healthy and delicious nutrition
It all began humbly in 1918 with the immediate goal of practically investigating how to improve nutrition in times of war-related food shortages. Today it is a major player in research on food and nutrition. The State of Bavaria has paved the way for this journey to the future: The Leibniz-Institute for Food Systems Biology at the Technical University of Munich is celebrating its 100th anniversary with a festive scientific symposium including high-ranking representatives from science, politics and the community.
June 14, 2018: New AiF project "Activity of amylase trypsin inhibitors" is launched
Amylase trypsin inhibitors are enzymes that are naturally present in gluten-containing cereals such as wheat and thus also in pastry products. Recent research results of the team around Prof. Dr. Dr. Detlef Schuppan of the Institute of Translational Immunology of the Mainz University Medical Center point out that it is not primarily gluten but enzymes that are responsible for the non-celiac wheat sensitivity. The symptoms of this disease occur mainly extraintestinal. These include drowsiness, fatigue, joint and muscle pain, skin changes and depressive moods. Likewise, existing chronic diseases can worsen. Schuppan estimates that in some people, the enzymes activate the innate immune system in the small intestine. In its activated state, it releases inflammation-promoting substances that might be responsible for the complaints of affected persons. Since the immune response is purely dose-dependent, it is sufficient, according to the scientists, to reduce enzyme uptake by about 80-95 percent in order to prevent the onset of symptoms. However, it is still unclear how the enzyme concentrations and activities in cereal products such as bread correlate with each other, or how much they are influenced by different manufacturing processes or the types of cereals that are used.
Sabrina Geißlitz and project leader Dr. Katharina Scherf from the Leibniz-LSB@TUM work closely together with Schuppan’s team to clarify these points. Their aim is to develop sensitive and reliable detection methods for service laboratories, which allow optimization of the manufacturing processes of bread and pastry leading to minimal enzyme content in the products. The result would be well-controlled bakery products that are more digestible for patients suffering from wheat sensitivity or irritable bowel syndrome.
The Project is funded by: Forschungsvereinigung Forschungskreis der Ernährungsindustrie e.V. (FEI) and by Arbeitsgemeinschaft industrieller Forschungsvereinigungen „Otto von Guericke“ e.V. (AiF) via the Federal Ministry for Economic Affairs and Energy.
June 9, 2018: Long Night of Sciences in Berlin
From 5 to 12 pm, at the Long Night of Sciences in Berlin, scientists of the Leibniz-LSB@TUM presented their research together with partners from the Leibniz Research Alliance "Sustainable Food Production and Healthy Nutrition" at the Headquarter of the Leibniz Association. At the booth of the Leibniz-LSB@TUM it was all about the questions: Is gluten generally harmful to health? Is spelt easier to digest than wheat? Are old wheat varieties better than new ones? Questions that the Leibniz-LSB@TUM scientists, together with colleagues from the Leibniz Institute of Plant Genetics and Crop Plant Research in Gatersleben are pursuing together in the "Wheatscan" project.
Cover Story: Leibniz-LSB@TUM Publication in the Journal of Agricultural and Food Chemistry
Dr. Katharina Scherf leads the team 'Functional Biopolymer Chemistry' at the Leibniz-LSB@TUM. Together with her peers, she discovered a new method to detect gluten. The scientists introduced this method in the April edition of the Journal of Agricultural and Food Chemistry. In susceptible people, even small amounts of gluten in their food may cause an inflammatory bowel disease known as celiac disease. Therefore, knowing whether grain products contain gluten and how much of it is present is crucial for everybody who is gluten-sensitive.
In the new method, the scientists couple liquid chromatography and mass spectrometry in a tandem procedure. This allows the quantitative analysis of even very small amounts of gluten in barley, rye and oat products. While previously available methods only provided data on the content of a specific gluten fraction (the prolamin fraction), the new method has the advantage of allowing the determination of the total gluten content. More…
Food Aroma Sensors – Aroma Receptors as 'Analytical Molecular Nose'
On April 10, 2018, while attending the major international trade show analytica in Munich (Germany), Dr. Dietmar Krautwurst talked about a new measuring system for the digitization of complex food-associated aromas. Dr. Dietmar Krautwurst, Head of Section II at the Leibniz-LSB@TUM, developed the measuring system together with his team. The aroma signatures obtained by using the measuring system will be useful for analytical and quality assurance purposes in the food producing industry.
100 Years of Molecular Food and Nutritional Research
On April 03, 2018, the Leibniz Institute for Food Systems Biology (Leibniz-LSB@TUM) will proudly look back at 100 years of excellence in molecular food and nutrition research. The institute started as Deutsche Forschungsanstalt für Lebensmittelchemie (DFA, German Centre for Food Chemistry) in the year 1918 when the Royal Bavarian Government established the institute as public trust. Privy Councilor Professor Theodor Paul MD, Chair of Pharmacology and Applied Chemistry at the University Munich, was appointed Founding Director. You find more information on the history of our institute here.
On Friday, June 15, 2018, we are going to celebrate our 100-Year Anniversary in the framework of a celebratory symposium.
If you like to celebrate with us, please send us a short note to register your attendance before March 23, 2018. Please send this note with your name, address, email address and telephone number to the following email address: firstname.lastname@example.org.
We would be delighted if you could help us celebrate our anniversary on June 15, 2018 in Freising!
TUM@Freising Event Series:
At the Restaurant Lindenkeller, Professor Thomas Hofmann elaborates on the topic "What do you taste when the meal tastes good?"
On March 13, 2018, Professor Dr. Thomas Hofmann, Chair of Food Chemistry and Molecular Sensory Science and Director of the Leibniz-Institute for Food Systems Biology at the TU Munich, gives a presentation on our senses of aroma and taste. After all, how drab would our lives be without the enjoyment of fragrances and aromas? Professor Hofmann will describe our sense of taste in all its complexity and will point out how scientists can influence the taste of our meals.