3. Predictive Chemoreceptor-mediated Human Biology
After intake, functional effector systems in food may induce biological activity in various ways. For example, effector molecules may target specific cell structures such as receptors and ion channels on cells of the oro-gastrointestinal tract or on blood immune cells. Furthermore, food effector systems may be affected by metabolization. Scientists of the institute pursue the objective to elucidate and predict the metabolic alteration of foodborne effector systems and their chemoreceptor-mediated biological action on the molecular level. This research will deliver new knowledge for the targeted development of healthier foods.
- Elucidation and modulation of the principles determining the translation of food effector systems into individualized activation patterns of biomolecular targets (receptors, ion channels, enzymes), signal transduction, and gene regulation processes of cells in the oro-gastrointestinal tract as well as the cellular immune system.
- Development of primary cell and new gene-edited (CRISPR/Cas) tailored screening systems for receptor- and ion channel-specific bioactivity.
- Elucidation of the chemoreceptor-relevant metabolome and its modulation through dietary intervention.
- Understanding and prediction of the dynamic processes underlying eating behaviors
- Knowledge creation on epigenetic programing and contribution to new personalized nutrition concepts.