Arbeitsgruppe Metabolic Function & Biosignals
Tel.: +49 8161 71-2930
Whats the context?
A couple of TRP (Transient receptor potential) channels are well known for the mediation of chemesthetic sensations, yet, their functions in non-sensory systems are less well understood.
What challenge is tackled?
Thus, clarifying the non-sensory function of these channels as well as identifying their endogenous ligands is of great scientific interest.
What is done?
Focusing on primary human immune cells the RNA-expression of TRP-channels as well as the cellular responses to known TRP-channel ligands are studied.
What has come out of your work?
These analyses showed that for example TRPV1 ligands from ginger modulate the human cellular immune response, indicating a natural role of this channel in the human immune system.
Whats the value?
Our work can provide a better general understanding regarding the function of chemosensory ion-channels in non-sensory systems.
|since 2019||Senior Researcher in the research group of Prof. Veronika Somoza|
|2017-2019||Head of the research group “Chemesthesis and Metabolism” at the Leibniz-Institute for Food Systems Biology at the Technical University of Munich (Leibniz-LSB@TUM)|
|2008-2017||Head of the research group “Food Composition Tables” at the DFA|
|2005-2008||Research scientist in the research group “Physiology” of Prof. Veronika Somoza at the then Deutsche Forschungsanstalt für Lebensmittelchemie (DFA)|
|2004-2005||Research scientist at the Botanical Institute, research group Plant Cell Biology, University of Kiel|
|1999-2004||PhD student at the Botanical Institute, research group Plant Cell Biology, University of Kiel|
|1992-1999||Studies in Food Chemistry at the University of Wuppertal|
Function of TRP-channels in human immune cells
Seminar “Experimental Methods of Nutrition Physiology” at the TUM
Schoenknecht C, Andersen G, Schmidts I, Schieberle P. Quantitation of Gingerols in Human Plasma by Newly Developed Stable Isotope Dilution Assays and Assessment of Their Immunomodulatory Potential. J Agric Food Chem. 2016 Mar 23;64(11):2269-79. doi: 10.1021/acs.jafc.6b00030. Epub 2016 Mar 9. PMID: 26939769.
Schoenknecht C, Andersen G, Schieberle P. A novel method for the quantitation of gingerol glucuronides in human plasma or urine based on stable isotope dilution assays. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Nov 15;1036-1037:1-9. doi: 10.1016/j.jchromb.2016.09.033. Epub 2016 Sep 26. PMID: 27700987.
Andersen G, Marcinek P, Sulzinger N, Schieberle P, Krautwurst D. Food sources and biomolecular targets of tyramine. Nutr Rev. 2019 Feb 1;77(2):107-115. doi: 10.1093/nutrit/nuy036. PMID: 30165672.