Kurzprofil Dr. Roman Lang

A balanced diet supplies sufficient amounts of macro- and micronutrients and is mandatory to secure complete functionality of the body and maintain good health. Beyond the pure intake of energy and building blocks, overall sensory attractiveness and individual preferences strongly affect the choice of foods, as eating and drinking is a daily procedure with fundamental hedonic aspects. The Biosystems Chemistry & Human Metabolism group isolates and purifies new compounds from food sources for structure elucidation and subsequent investigation of bioactivity, e.g. sensory activity and receptor activation. We target non-volatile dietary bioactives and tastants, their formation and the effect of food processing, the metabolic fate after consumption and the structure and bioactivity of metabolites. We plan and participate in human intervention studies and apply untargeted and targeted UPLC-MS based methods to identify and quantify food-derived compounds in blood and urine. Our work expands the knowledge on food composition, options for modulation of food constituents via processing, and human metabolism.

2009 – Award of the “Deutschen Gesellschaft für Qualität (DGQ)” for contributions to the knowledge on niacin in coffee (Lang, Wahl et al., 2010; Lang, Wahl et al., 2011; Lang, Yagar et al., 2013; Lang, Dieminger et al., 2013)

(See ORCID for complete list)

1. Schulz, A.; Lang, R.*; Behr, J.; Hertel, S.; Reich, M.; Kümmerer, K.; Hannig, M.; Hannig, C.; Hofmann, T.* Targeted metabolomics of pellicle and saliva in children with different caries activity. (2020) Sci. Rep. 10(1), 697, https://doi.org/10.1038/s41598-020-57531-8

2. Lang, T.; Lang, R.; Di Pizio, A.; Mittermeier, V.; Schlagbauer, V.; Hofmann, T.; Behrens, M.* (2020) Numerous compounds orchestrate coffee’s bitterness. J.Agric.Food Chem, 68,24, 6692 – 6700, https://doi.org/10.1021/acs.jafc.0c01373.

3. Lang, R.; Lang, T.; Bader, M.; Beusch, A.; Schlagbauer, V.; Hofmann, T.* (2017) High-Throughput Quantitation of Proline Betaine in Foods and Suitability as a Valid Biomarker for Citrus Consumption. J. Agric. Food Chem. 65,8,1613-1619. DOI: 10.1021/acs.jafc.6b05824

4.  Lang, R.; Klade, S.; Beusch, A.; Dunkel, A.; Hofmann, T.* (2015) Mozambioside is an Arabica-Specific Bitter-Tasting Furokaurane Glucoside in Coffee Beans. J. Agric. Food Chem. 63, 10492-10499, DOI: 10.1021/acs.jafc.5b04847

5. Lang, R.*; Fromme, T.; Beusch, A.; Lang, T.; Klingenspor, M.; Hofmann, T. (2014) Raw coffee based dietary supplements contain carboxy-atractyligenin derivatives inhibiting mitochondrial adenine-nucleotide-translocase. Food Chem. Tox. 70, 198-204, DOI: 10.1016/j.fct.2014.05.017

6. Lang, R.; Dieminger, N.; Beusch, A.; Lee, Y.-M.; Dunkel, A.; Suess, B.; Skurk, T.; Wahl, A.; Hofmann, T.* (2013) Bioappearance and pharma-cokinetics of bioactives upon coffee consumption. Anal. Bioanal. Chem. 405, 8487-8503, DOI: 10.1007/s00216-013-7288-0

7. Lang, R.; Wahl, A.; Stark, T.; Hofmann, T.* (2011) Urinary N-methyl-pyridinium and trigonelline as candidate dietary biomarkers of coffee consumption.Mol. Nutr. Food Res. 55, 1613-1623, DOI: DOI: 10.1002/mnfr.201000656

8. Lang, R.*; Wahl, A.; Skurk, T. Yagar, E.F.; Schmiech, L.; Eggers, R.; Hauner, H.; Hofmann, T.* (2010) Development of a Hydrophilic Liquid Interaction Chromatography-High-Performance Liquid Chromatography-Tandem Mass Spectrometry Based table Isotope Dilution Analysis and Pharmacokinetic Studies on Bioactive Pyridines in Human Plasma and Urine after Coffee Consumption. Anal. Chem. 82, 1486-1497, DOI: 10.1021/ac902616k

9. Lang, R.; Yagar, E.-F.; Eggers, R.; Hofmann, T.* (2008) Quantitative Investigation of Trigonelline, Nicotinic Acid, and Nicotinamide in Foods, Urine, and Plasma by Means of LC-MS/MS and Stable Isotope Dilution Analysis. J. Agric. Food Chem, 56, 11114-11121, DOI: 10.1021/jf802838s

 *=corresponding author