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Kurzprofil PD Dr. Dietmar Krautwurst

Unit Head Odor Systems Biosignals & Chemoreception

Lise-Meitner-Str. 34
85354 Freising
Germany
Tel.: +49 8161 71-2634

E-Mail   ORCID   Curriculum Vitae

 

Research Interests:

  • De-orphanisation of all human odorant receptors
  • Food-typical key odorants, semiochemicals, and metabolites as agonists and antagonists of odorant receptors
  • Extra-nasal and extra-oral olfactory and taste receptors
  • Systems Biology of food-related adequate stimulus systems, receptors, and immune cell sub-systems
  • Cell-free chemosensory receptor sensor systems

Selected Publications:

Di Pizio A, Behrens M, Krautwurst D (2019) Beyond the Flavour: The Potential Druggability of Chemosensory
G Protein-Coupled Receptors. International journal of molecular sciences 20

Haag F, Ahmed L, Reiss K, Block E, Batista VS, Krautwurst D (2019) Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3. Cell Mol Life Sci

Hofmann T, Krautwurst D, Schieberle P (2018) Current Status and Future Perspectives in Flavor Research: Highlights of the 11th Wartburg Symposium on Flavor Chemistry & Biology. Journal of agricultural and food chemistry 66: 2197-2203

Geithe C, Noe F, Kreissl J, Krautwurst D (2017a) The Broadly Tuned Odorant Receptor OR1A1 is Highly Selective for 3-Methyl-2,4-nonanedione, a Key Food Odorant in Aged Wines, Tea, and Other Foods. Chem Senses 42: 181-193

Geithe C, Protze J, Kreuchwig F, Krause G, Krautwurst D (2017b) Structural determinants of a conserved enantiomer-selective carvone binding pocket in the human odorant receptor OR1A1. Cell Mol Life Sci 74: 4209-4229

Marcinek P, Geithe C, Krautwurst D (2017) Chemosensory G Protein-Coupled Receptors (GPCR) in Blood Leukocytes. In: Taste and Smell, Krautwurst D. (ed.) pp. 151-173. Springer: Berlin, Heidelberg

Noe F, Frey T, Fiedler J, Geithe C, Nowak B, Krautwurst D (2017a) IL-6–HaloTag® enables live-cell plasma membrane staining, flow cytometry, functional expression, and de-orphaning of recombinant odorant receptors. Journal of Biological Methods 4: e81

Noe F, Polster J, Geithe C, Kotthoff M, Schieberle P, Krautwurst D (2017b) OR2M3: A Highly Specific and Narrowly Tuned Human Odorant Receptor for the Sensitive Detection of Onion Key Food Odorant 3-Mercapto-2-methylpentan-1-ol. Chem Senses 42: 195-210

Geithe C, Andersen G, Malki A, Krautwurst D (2015) A Butter Aroma Recombinate Activates Human Class-I Odorant Receptors. Journal of agricultural and food chemistry 63: 9410-9420

Malki A, Fiedler J, Fricke K, Ballweg I, Pfaffl MW, Krautwurst D (2015) Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes. Journal of leukocyte biology 97: 533-545

Dunkel A, Steinhaus M, Kotthoff M, Nowak B, Krautwurst D, Schieberle P, Hofmann T (2014) Genuine Geruchssignaturen der Natur - Perspektiven aus der Lebensmittelchemie für die Biotechnologie. Angewandte Chemie 126: 7250-7271

Babusyte A, Kotthoff M, Fiedler J, Krautwurst D (2013) Biogenic amines activate blood leukocytes via trace amine-associated receptors TAAR1 and TAAR2. Journal of leukocyte biology 93: 387-394

Shirokova E, Raguse JD, Meyerhof W, Krautwurst D (2008) The human vomeronasal type-1 receptor family--detection of volatiles and cAMP signaling in HeLa/Olf cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22: 1416-1425

Shirokova E, Schmiedeberg K, Bedner P, Niessen H, Willecke K, Raguse JD, Meyerhof W, Krautwurst D (2005) Identification of specific ligands for orphan olfactory receptors. G protein-dependent agonism and antagonism of odorants. The Journal of biological chemistry 280: 11807-11815

Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002) The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nature genetics 32: 397-401

Krautwurst D, Yau KW, Reed RR (1998) Identification of ligands for olfactory receptors by functional expression of a receptor library. Cell 95: 917-926

For further papers please see ORCID