Kurzprofil Dr. Sanjai Karanth

Research Group Mechanoreceptors

Lise-Meitner-Str. 34
85354 Freising
Tel.: +49 8161 71-2985

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Texture based impressions significantly influences the mouthfeel and sensory perception of food intake. While chemosensory induced mechanisms are well known, the contribution arising from physical or mechanical attributes towards mouthfeel has been less explored.

Mechanoreceptors along with chemoreceptors tend to contribute to the overall mouthfeel. Deducing such mechanotransduction and its related properties can explain signal transduction better.

To answer above queries, two broad approaches are being pursued. First on a single molecule level where biomimetic system called nanodiscs is being developed to probe the protein’s activity and its role in mechanoreception.  It is then compared on a cellular level to confirm whether the proteins act alone or in unison to explore its interplay.  The proteins currently under investigation are Piezo and TRP channels.

The gained scientific information can help in better development of food formulation that is not only limited to better nutrition but also increased satiation and provide better overview on the oral perception of food.

Since 2023 Postdoctoral Researcher, Leibniz Institute for Food Systems Biology at the TU Munich
2021-2022 Postdoctoral Researcher, Institute of Physics, Kent State University, Ohio, USA
2017-2021 PhD graduate, Institute of Chemistry, University of Greifswald, Germany
2014-2017 MSc Biophysics, University of Ulm, Germany
2016 Scholarship from Ulm University funded by BMBF, Germany

Mechanical characterization of Piezo proteins in cell and biomimetic systems

Meesaragandla, B., Blessing, D. O., Karanth, S., Rong, A., Geist, N., & Delcea, M. (2023). Interaction of polystyrene nanoparticles with supported lipid bilayers: impact of nanoparticle size and protein corona. Macromolecular Bioscience, 2200464.

Karanth, Sanjai, et al. "Identification of a critical lipid ratio in raft-like phases exposed to nitric oxide: An AFM study." Biophysical Journal 120.15 (2021): 3103-3111.

Karanth, Sanjai, and Mihaela Delcea. "Nitrosative stress affects the interaction of integrin alphaIIbbeta3 with its ligands." Biochimica et Biophysica Acta (BBA)-Biomembranes 1862.5 (2020): 183198.

Meesaragandla, B., Karanth, S., Janke, U., & Delcea, M. (2020). Biopolymer-coated gold nanoparticles inhibit human insulin amyloid fibrillation. Scientific Reports, 10(1), 7862.